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Rahul Rundla
Dr. Tara Chand
Ashish Jain
Nehal Sharma
Keywords:
Tranexamic acid, Liposomes, Liposomal gel, Melasma, Carbopol 940, Topical delivery.
Abstract:
The present study was carried out to develop a tranexamic acid-loaded liposomal gel for topical treatment of melasma. Tranexamic acid-loaded liposomes were prepared by the thin-film hydration method using different drug-to-lipid ratios, cholesterol and Tween 80 concentrations. The prepared liposomes were evaluated for vesicle size, PDI, zeta potential, entrapment efficiency and drug content. L5 was selected as the optimized formulation. The optimized liposomes were incorporated into Carbopol 940 gel. The final gel showed good appearance, homogeneity, pH, viscosity, spreadability and drug content. The drug content was 96.84 ± 0.78%. In-vitro drug release after 12 hours was 84.26 ± 1.72%, showing slower release than the plain gel. The developed tranexamic acid liposomal gel showed satisfactory properties and may be useful for topical delivery in melasma.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 3
September 2026
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PUBLISHED
September 2026
ISSUE
Vol. XIX, Issue 3
SECTION
Articles
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