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Shahin Banu
Mr. Rakesh Sharma
Keywords:
Alangium salvifolium, Traumatic Brain Injury, Antioxidant, Nootropic, Neuroprotection, Phytochemistry, Oxidative Stress.
Abstract:
Traumatic brain injury (TBI) plays a critical role in understanding the therapeutic potential of Alangium salvifolium in traumatic brain injury. The involvement of oxidative stress, mitochondrial dysfunction, excitotoxicity, and inflammatory cascades contributes significantly to neuronal degeneration and cognitive impairment. Numerous preclinical investigations have demonstrated that phytochemical-rich extracts can modulate these pathways effectively. The presence of flavonoids, alkaloids, and phenolic compounds contributes to free radical scavenging, enhancement of endogenous antioxidant enzymes, and stabilization of neuronal membranes. Furthermore, experimental animal models have shown improvements in spatial memory, learning behavior, and neurochemical balance following administration of plant extracts. These findings strongly support the hypothesis that natural compounds can serve as multi-targeted therapeutic agents in neurodegenerative conditions such as traumatic brain injury. The involvement of oxidative stress, mitochondrial dysfunction, excitotoxicity, and inflammatory cascades contributes significantly to neuronal degeneration and cognitive impairment. Numerous preclinical investigations have demonstrated that phytochemical-rich extracts can modulate these pathways effectively. The presence of flavonoids, alkaloids, and phenolic compounds contributes to free radical scavenging, enhancement of endogenous antioxidant enzymes, and stabilization of neuronal membranes. Furthermore, experimental animal models have shown improvements in spatial memory, learning behavior, and neurochemical balance following administration of plant extracts. These findings strongly support the hypothesis that natural compounds can serve as multi-targeted therapeutic agents in neurodegenerative conditions such as traumatic brain injury. The involvement of oxidative stress, mitochondrial dysfunction, excitotoxicity, and inflammatory cascades contributes significantly to neuronal degeneration and cognitive impairment. Numerous preclinical investigations have demonstrated that phytochemical-rich extracts can modulate these pathways effectively. The presence of flavonoids, alkaloids, and phenolic compounds contributes to free radical scavenging, enhancement of endogenous antioxidant enzymes, and stabilization of neuronal membranes. Furthermore, experimental animal models have shown improvements in spatial memory, learning behavior, and neurochemical balance following administration of plant extracts. These findings strongly support the hypothesis that natural compounds can serve as multi-targeted therapeutic agents in neurodegenerative conditions such as traumatic brain injury.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 1
March 2026
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PUBLISHED
March 2026
ISSUE
Vol. XIX, Issue 1
SECTION
Articles
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