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Agarwal Amishaben Pravinbhai
Dr Divya Singh
Keywords:
Moringa oleifera, nephroprotection, antioxidant, drug-induced nephrotoxicity, gentamicin, oxidative stress.
Abstract:
Drug-induced nephrotoxicity is a major cause of acute kidney injury, commonly associated with drugs such as gentamicin that generate oxidative stress and inflammation in renal tissues. Natural antioxidants have emerged as potential therapeutic agents, among which Moringa oleifera is widely recognized due to its rich phytochemical composition. This review evaluates the antioxidant-mediated nephroprotective effects of Moringa oleifera in drug-induced renal damage. Evidence from preclinical studies indicates that Moringa oleifera enhances antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), while reducing lipid peroxidation markers like malondialdehyde (MDA). It also exerts anti-inflammatory and anti-apoptotic effects by regulating cytokines and signaling pathways. These effects lead to significant improvement in renal biomarkers such as serum creatinine and urea, along with histopathological recovery of kidney tissues. Thus, Moringa oleifera shows promising nephroprotective potential; however, further clinical validation is required.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 1
March 2026
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PUBLISHED
March 2026
ISSUE
Vol. XIX, Issue 1
SECTION
Articles
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