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Khushboo Kumari
Dr. Mayank Bansal
Ashutosh Sharma
Manoj Kumar Gupta
Keywords:
Caffeine, central nervous system depression, adenosine receptor antagonist, alertness, medicinal uses, neuroprotection
Abstract:
The study aims to formulate and evaluate fast-dissolving caffeine tablets (FDTs) using different polymers to enhance dissolution and bioavailability for effective CNS depression management.
Methods: Fast-dissolving tablets were prepared using various polymers, including Cross carmelose Sodium, Sodium starch glycolate and Kyron T-314 by direct compression method. The formulations were evaluated based on pre-compression and post-compression parameters, such as hardness, friability, disintegration time, and in vitro drug release. A comparative analysis was conducted to identify the most effective polymer for optimizing the tablet’s performance.
Results: The results indicated that polymer selection significantly influenced the disintegration time and drug release profile. Among the tested formulations, Kyron T-314 exhibited the fastest disintegration and highest dissolution rate, making it the most suitable candidate for fast-dissolving caffeine tablets.
Conclusion: The study confirms that fast-dissolving caffeine tablets formulated with an optimized polymer can provide rapid onset of action, improving patient compliance and therapeutic efficacy in CNS depression management. Further in vivo studies and stability assessments are recommended to validate these findings.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XVIII, Issue 1
March 2025
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PUBLISHED
March 2025
ISSUE
Vol. XVIII, Issue 1
SECTION
Articles
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