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Kamal Kumar Singh
Dr. Mohit Khandelwal
Dr. Dilip Agrawal
Keywords:
Ultra-deformable, Vesicular, Lipid-based, Macromolecules.
Abstract:
The objective of this study was to design, develop, and evaluate an ultra-deformable lipid-based vesicular system for the topical delivery of podophyllotoxin, a potent anticancer and antiviral agent. Podophyllotoxin's therapeutic application is often restricted due to its poor aqueous solubility, systemic toxicity, and limited skin permeability. To address these limitations, ultra-deformable lipid vesicles were formulated to enhance drug solubility, stability, and penetration through the skin. The vesicles were prepared using phospholipids and surfactants via thin-film hydration and optimized for particle size, zeta potential, entrapment efficiency, and deformability. Key characterization studies, including morphological analysis (TEM), in vitro release, and ex vivo skin permeation studies, were conducted. The optimized formulation exhibited a nanoscale size range (<200 nm), high deformability, and significant drug encapsulation efficiency. In vitro release studies demonstrated sustained drug release over 24 hours, while ex vivo permeation studies confirmed enhanced skin penetration compared to conventional formulations. Furthermore, the vesicles showed superior antiproliferative activity against cancer cell lines and reduced cytotoxicity in healthy cells. This study concludes that ultra-deformable lipid vesicles are a promising delivery system for podophyllotoxin, offering improved topical bioavailability, reduced systemic exposure, and enhanced therapeutic efficacy, paving the way for more effective topical therapies.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XVII, Issue 4
December 2024
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PUBLISHED
December 2024
ISSUE
Vol. XVII, Issue 4
SECTION
Articles
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