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Sanjay Sahu
Ashutosh Sharma
Dr. Mayank Bansal
Yogesh Kumar Garg
Keywords:
hydroxytryptamine, fenugreek powder, beclofen, crospovidone, migraine, natural superdisintegrants, and dissolution time
Abstract:
Over the last two to three decades, there has been a notable growth in the demand for pills that dissolve quickly. In this study, the effects of conventional, synthetic, and natural superdisintegrants are compared in the formulation of Beclofen-containing fast-dissolving tablets. Beclofen, a new anti-migraine drug, is a potent and specific 5-hydroxytryptamine1B/1D receptor agonist that is thought to be more effective than traditional triptans at treating acute migraine attacks. Using superdisintegrants, nine Beclofen fast-dissolving tablet (FDT) formulations were made and examined against official guidelines, meeting all requirements. Using the direct compression approach, many formulations were created using four different superdisintegrants: sodium starch glycolate, crospovidone, and the natural superdisintegrant fenugreek powder, at three concentrations (4%, 6%, and 8%). In vitro dissolution tests showed that formulation FL5 achieved 98.50% drug release in 3 minutes, and it also showed the quickest disintegration time.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XVII, Issue 4
December 2024
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PUBLISHED
December 2024
ISSUE
Vol. XVII, Issue 4
SECTION
Articles
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