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Mr. Rohitashav Sharma
Ravisha Mathur
Mrs. Vandana Sharma
Dr. Gajendra Singh Tyagi
Keywords:
Metabolize drugs, gut microbiota, microbiome, pharmacokinetics, pharmacodynamics, probiotics and prebiotics.
Abstract:
The human gut microbiome, composed of trillions of microorganisms, performs a essential role in numerous components of fitness and disorder, together with drug metabolism. This assessment examines the rising proof of ways intestine microbes impact the pharmacokinetics and pharmacodynamics of prescribed drugs. Gut microbiota can metabolize drugs via enzymatic sports that alter their chemical structure, which could beautify or decrease drug efficacy and alter toxicity profiles. Such microbial interactions can lead to sizable versions in drug absorption, metabolism, and excretion, resulting in various therapeutic consequences and aspect effects amongst people. Recent advancements in microbiome research have unveiled the complicated mechanisms through which intestine microbes impact drug metabolism, revealing new possibilities for personalised remedy. By profiling an character's microbiome, clinicians may additionally tailor drug therapies to optimize efficacy and reduce damaging results. Additionally, interventions such as probiotics and prebiotics offer capacity techniques to modulate the microbiome and enhance drug responses. This evaluation synthesizes modern information on the interactions among intestine microbiota and prescription drugs, discusses the results for drug improvement and scientific exercise, and descriptions destiny research directions aimed toward integrating microbiome insights into personalised healing methods. Understanding those interactions is important for advancing precision medicine and enhancing patient care thru more effective and more secure drug remedies.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XVII, Issue 3
September 2024
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PUBLISHED
September 2024
ISSUE
Vol. XVII, Issue 3
SECTION
Articles
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