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Shabana Zaffar
Anchal Kumar Verma
Ritik Raushan
Nardev
Mukesh Sharma
Ashok Kumar Sharma
Keywords:
Fast Dissolving, Oral Dissolving, Film, Tablet, Comparative.
Abstract:
In recent years, pharmaceutical formulations have seen significant advancements in enhancing patient compliance and convenience through innovative dosage forms such as fast dissolving tablets (FDTs) and oral dissolving films (ODFs). This comparative analysis evaluates the key characteristics, advantages, and limitations of these two novel drug delivery systems. Fast dissolving tablets are solid dosage forms that disintegrate rapidly in the oral cavity without the need for water, offering rapid drug absorption and improved bioavailability. They are typically composed of superdisintegrants, which facilitate quick disintegration upon contact with saliva. Conversely, oral dissolving films are thin, flexible strips that dissolve rapidly when placed on the tongue or in the oral cavity, releasing the drug for absorption through buccal or sublingual routes. This analysis reviews various factors influencing the preference and efficacy of FDTs and ODFs, including formulation development, manufacturing processes, stability, portability, and patient acceptability. Both dosage forms have shown advantages in terms of ease of administration, reduced risk of choking, and enhanced patient compliance, particularly beneficial for pediatric, geriatric, and psychiatric patients.
However, challenges such as taste masking, stability under varying environmental conditions, and regulatory considerations pose significant hurdles for widespread adoption. Furthermore, differences in manufacturing complexity and cost-effectiveness influence the commercial viability of these dosage forms.
In conclusion, while both fast dissolving tablets and oral dissolving films offer promising alternatives to conventional oral dosage forms, their suitability depends on specific therapeutic requirements, patient preferences, and regulatory constraints. Further research and development efforts are necessary to optimize these formulations and expand their applications in modern pharmaceutical practice.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XVII, Issue 1
March 2024
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PUBLISHED
March 2024
ISSUE
Vol. XVII, Issue 1
SECTION
Articles
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